The man who would become closely associated with the rise of gospel music was the self-described "son of a preacher man" whose musical talents were so widely recognized that gospel tunes were called "Dorseys," began his career on the seedy side of the street (literally, in the prostitute-laden dives on Decatur Street near Auburn Avenue). It was here that he met Gertrude "Ma" Rainey and "Tampa Red" Whitaker, with whom he would team on a number of occasions early in his career. Whitaker and Dorsey played an unusual blend of blues, integrating many influences including country, jazz and what would become known as gospel or gospel blues.

In 1916 Dorsey moved from Atlanta to Chicago where he became noted for his double-meaning songs that were popular in bars and stag parties at which he was frequently called to play. It was here that he became known as "Georgia Tom" and began an extended collaboration with Whitaker, including the hit "It's Tight Like That."

In 1929 he began his long association with gospel music, incorporating elements from his blues background and African-American spirituals with Christian hymns. The blend was an instant success whose appeal crossed racial lines even in the segregated South. His most famous song is "Precious Lord, Take My Hand," a nation-wide hit in both black and white circles. Unfortunately, the song was inspired by the death of his wife and daughter. The following year Dorsey formed National Convention of Gospel Choirs and Choruses, which he lead for 40 years. Although he continued to write songs throughout his life, Dorsey did not record after 1934.

"Peace in the Valley" is perhaps his most widely recognized work.